How sexual contacts with outsiders contribute to HIV infections within communities - Medical News

Wednesday 5 March 2014 - 2am PSTWed 5 Mar 2014 - 2am PST

While a number of approaches can protect against and manage transmission and spread, their reliable use depends on understanding the sex-related networks within and between neighborhoods. A paper published in PLOS Medicine reports a detailed analysis with surprising outcomes from the Rakai area in Uganda, among the most studied locations of the HIV/AIDS outbreak in Africa.

Mary K. Grabowski, from Johns Hopkins Bloomberg Institution of Hygienics, led a global team of scientists in an initiative to check the hypothesis that most people which acquire HIV outside their house are contaminated through sex with an individual from their regional neighborhood. However, learning 46 neighborhoods within the Rakai area in Uganda, the researchers discovered that intros of HIV from outside the neighborhood are frequent and seem to add significantly to sustaining the HIV outbreak within the neighborhood. While the largest fraction of new infections occur within a home, the majority of new infections beyond the house appear to be contractedwith companions from outside the neighborhood.

Several of the data depend on the accuracy of self-reported sex-related collaborations, yet the searchings for were regular between three various methods the scientists used to analyze the problem. And while it is not recognized whether the scenario in neighborhoods beyond Rakai is comparable, these outcomes propose that HIV infectionsfrom outside the neighborhood are usual, and that HIV prevention projects require to look past neighborhoods.

Short article: The Job of Viral Introductions in sustaining Community-Based HIV Epidemics in Rural Uganda: Proof from Spatial Clustering, Phylogenetics, and Egocentric Transmission Models, Grabowski MK, Lessler J, Redd AD, Kagaayi J, Laeyendecker O, et al.

PLoS Med. DOI:10.1371 / journal. pmed.1001610, published 4 March 2014.


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